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Saffron should be possible. It is a fall blooming crocus that should be fine in your area. This article should help:
https://www.gardeningknowhow.com/edible/herbs/saffron/growing-saffron-crocus.htm

Vanilla is another matter. It is an orchid and needs a very specific environment of heat and humidity but not direct light. If you feel you would be able to provide that, this article will be helpful:
http://web.extension.illinois.edu/macon/palette/091213.html

Use a fertilizer with higher phosphorus to help with blooming. Use the fertilizer as directed on the package. Fertilizers vary from type, so I can't give specific amounts due to this.

The harvest period is usually anywhere from late September to late December and is best performed early in the morning. Blossoms are at their maximum for about 15 to 20 days. The harvested stigmas should be placed in a dark, warm and dry room for five to seven days in order to dry.

If slugs are a problem, this article should help: https://www.gardeningknowhow.com/plant-problems/pests/facts-about-slugs-and-how-to-kill-garden-slugs.htm

Not sure of the exact math but I do know that about 50-60 saffron flowers are needed to produce about 1 tablespoon of saffron spice.

I would suggest appropriate annuals and perennials for the location that will not crowd or overtake the crocus. Your choices will depend on your USDA hardiness zone, size, colors, sun, soil type and many other variables.

These are normally planted in the fall but if you live in an ideal climate, it shouldn't hurt to plant them in spring. It might depend on the bulb's maturity as to whether or not it blooms. This article should help you: https://www.gardeningknowhow.com/edible/herbs/saffron/growing-saffron-crocus.htm