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It sounds like a possible fungus attack. Also in the hotter months of the year the color is not as vibrant as in the early spring and then again later in the year when temps cool down. Spray all of the roses with a good fungicide such as Green Cure or if you cannot find the Green Cure locally or on-line try Immunox as directed on the label. There is also a product by Bayer called Tree and Shrub granules. Giving all the rosebushes some of that product will typically handle the problem as well.

I sprinkle 1/2 cup of Epsom Salts around the base of the rosebushes and work it into the soils a bit. Then water in well. This can be done the next day if desired, same goes for the Epsom Salts water application.

You can shape prune the rosebushes anytime. With Knockout roses you do not want to prune too heavily as you will cause a longer delay in the new blooms coming on. They are what is known these days as Self Cleaning Rosebushes. They will continue to bloom without the need to deadhead or prune if so desired. Rosebushes are related to apple trees, pruning them helps send a message for more growth. The difference between Knockout roses and other roses is how their bloom cycles work. Pruning them to keep in an area and or shape can be done anytime, just be aware that it will through off their bloom cycle for the areas pruned.

Stan The Rose Man
Consulting Rosarian
Gardening Know How

From the photograph it is clear that your rose has been attacked by any of a number of types of caterpillar. Spray with an insecticide eg malathion and the plant should recover.

The good thing is that the leaves are healthy, so the plant should thrive. Remove the dead flowers, and the bush will concentrate its energies on establishing a strong root system in its current location, and send out vibrant new stems and leaves. Good luck.

If the rosebush is well watered and fed, then it could be that either the rosebush is not happy in the pot and needs to be planted in a bigger pot or in the ground. Or something got poured into the pot that is having a very negative effect upon the rosebush. If something got poured into the pot, the only option is to move the rosebush to a new pot with new soils.