Q.What Can I Grow Over A Septic/drainfield?
It is a full sunny location. I want to replace the grass with low water plants/flowers/groundcover.

Certified GKH Gardening Expert
I would recommend cacti and succulents for this job, like Barrel Cactus or Agave. You could opt for Texas Sage, as well. These will help improve the condition of the soil while being almost free of maintenance. Other than keeping an eye on and removing any dead or dying growth, all are pretty care-free.
https://www.gardeningknowhow.com/ornamental/cacti-succulents/agave/growing-agave.htm
https://www.gardeningknowhow.com/ornamental/shrubs/texas-sage/growing-texas-sage-plants.htm
https://www.gardeningknowhow.com/ornamental/cacti-succulents/agave/growing-agave.htm
Here are some articles that will offer some information: