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Your best bet to take care of these runners is to dig them up. If you use weed killer on them, that could harm the mother plant.

To control the runners in the future, you will need to put a barrier in the ground. It will need to go down at least 12 inches, 18 is better, into the ground.

I would suggest laying wet newspaper in the area and covering it with a layer of mulch, such as straw.

It sounds like a witch's broom. You can just pull them. This article will explain more:
https://www.gardeningknowhow.com/ornamental/trees/tgen/witches-broom-disease.htm

Raspberries are self fruitful, which means there have both male and female flowers on the same plant. One by itself will produce fruit.

This could be due to an issue with Raspberry Bud Moth. The larvae of the moth attack unopened buds, where they tunnel inside and cause extensive damage to the plants. As a result, the plants may not put out any fruit. Remove affected buds and any damaged canes or branches. Treat with appropriate insecticide.

There are many reasons this can happen to a plant. Most likely it is a watering issue. Try increasing water. This article has some other suggestions as to what it might be:
https://www.gardeningknowhow.com/plant-problems/environmental/plant-leaves-turn-yellow.htm