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You're in USDA Zone 6b (zip code 63334, northeast Missouri), so yes — there’s a slight adjustment worth noting:

Caladiums are not cold-hardy in your zone, so you'll need to plant them after your last frost,each year, typically around mid-to-late April or early May, once the soil hits 70°F (21°C). If the area stays cool longer, you might need to wait a bit longer or start them indoors in pots to give them a head start.

Also:
In your zone, you'll need to dig up the tubers in fall before your first frost (usually mid-October), let them dry, and store them indoors until spring. Otherwise, they won't survive winter.

https://www.gardeningknowhow.com/ornamental/bulbs/caladium/caladiums-care.htm