Certified GKH Gardening Expert
Were the grass and weeds killed before tilling? If not, they will likely grow back. Weed and feed is for actively growing lawns to add nitrogen and kill existing weeds.
Mulch can be used with weed block to hide its appearance and further conserve moisture and reduce weeds. It's up to you whether you want to add weed block. If you have some really invasive weeds, you may want to add it. If the weed problem is not that bad, you don't really need it. You also can lay wet newspaper or cardboard under the mulch to reduce weeds.
https://www.gardeningknowhow.com/garden-how-to/projects/how-to-solarize-garden-beds-to-eliminate-garden-pests-in-the-soil.htm
https://www.gardeningknowhow.com/plant-problems/weeds/weed-barriers-in-gardens.htm