Q.Organ pipe cactus
What are the fluffs of cotton where the thorns should be?

Downtoearthdigs
Answered on April 9, 2016
This is likely Scale pests.
They can be scraped away from the plant.
Neem Oil can also be used to treat Scale.
Here are some links with more information.
https://www.gardeningknowhow.com/ornamental/cacti-succulents/organ-pipe-cactus/organ-pipe-cactus-care.htm
https://www.gardeningknowhow.com/plant-problems/pests/pesticides/neem-oil-uses.htm
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