Q.Lower Leaves Of Trumpet Vine Cuttings Turning Brown With Rust Like Appearance,
The cutings have taken well and are growing fairly quickly. Have tried anti rust spray with no effect.

Certified GKH Gardening Expert
Since soil for rooting cuttings does not contain much nutrients, it is likely that it is deficient in multiple elements.
Potting up to the next container with fresh compost and potting mix will be best, but you could feed with nutrients, should you need to keep it smaller in stature.
This article will help you with their care:
https://www.gardeningknowhow.com/ornamental/vines/trumpet-vine/growing-trumpet-vines.htm