Q.isoxaben and atrazine
Is it okay to apply granular isoxaben and atrazine at the same time on st. Augustine lawn? What about spray?
If you have the need to use a pre emergent herbicide to control weeds, I would choose one product and use according to the manufacturers application rates.
It also is wise to verify the weed type and use a herbicide specific to that weed or weeds.
Mixing two herbicides is not advised.
Choose the application process that best meets the needs of your lawn and it's surroundings.
You may also want to check with your County Extension Office to seek advice on the best product to use in your region.
Here is a link to help you locate your nearest office.
https://www.gardeningknowhow.com/extension-search/
https://www.gardeningknowhow.com/lawn-care/specific/st-augustine-grass/st-augustine-grass.htm
https://www.gardeningknowhow.com/plant-problems/weeds/pre-emergent-herbicides.htm