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I do have a remedy that I use personally. It is ok if you don't have, or can't get all ingredients, but the more you have the better it works. this is safe for all plants, and will not hurt you either. Just don't skimp on the soil amendment. The recipe is as follows:

First, you will want to prime the ground with dolomitic lime, then spread wettable sulfur to Kill off any infection in the soil. I Also like to spray the plant itself. Mix a few drops of one or more of these ingredients into warm water with a spoonful of coconut oil: Rosemary oil, lavender oil, neem oil, garlic oil, cinnamon extract/oil and for really bad cases, also add clove oil.

Both are quite hardy, and don't usually need any time to acclimate. If you feel that you want to do this just to be sure, then leaving them outside for a few hours at a time each day for a week will be plenty of time to acclimate. They won't need this, but it is always good practice anyway.

Your native columbine, Aquilegia canadensis, does well in shade. The hybrids want at least part sun to bloom heavily. You can plant them now after acclimating them to outdoor conditions if they have been inside. They can handle frost.

Downy mildew is most common in spring, where temperatures are cooler and rain is plentiful. Yellowing or mottling on leaves is common with a downy, gray or white coating on underside.
Powdery mildew is more common in late summer when humidity is high. Here is info on how to treat them:

https://www.gardeningknowhow.com/plant-problems/disease/downy-mildew.htm
https://www.gardeningknowhow.com/plant-problems/disease/powdery-mildew-homemade-and-organic-remedies.htm

Columbines bloom in the spring and if planted from seed, won't bloom till the second year. Here are growing tips:

https://www.gardeningknowhow.com/ornamental/flowers/columbine/columbine-flower.htm

We don't make recommendations but you can contact a local nursery for a recommendation or the nearest extension agent.

https://www.gardeningknowhow.com/extension-search