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They are more determinate than tomatoes, so I wouldn't prune them. However, as with tomatoes, this is more of a personal choice so you could prune them, but it will reduce your harvest. You may also want to explore the use of a trellis or cage to help make the plant less unwieldy. Most people find it easier to simply allow the plant to sprawl.

We do not yet have a recipe section on the site, but I would recommend allrecipes.com (http://allrecipes.com/search/results/?wt=tomatillo&sort=re) Salsa is the most common use for tomatilloes.

Tomatillos are related to tomato plants and share many of the same growing conditions, as well as problems. Therefore, this article on lack of tomato fruit should be helpful with tomatillos too: https://www.gardeningknowhow.com/edible/vegetables/tomato/tomato-blossoms-no-tomatoes.htm

Without two plants, it is unlikely that the plant will produce fruit. They may produce a few, but not much more than that. Pulling it up would be up to you. Perhaps you could find a mature plant at a local nursery that you could purchase to bring home and make the first one produce.

It has been a hard summer on nightshade vegetables, with the high heat and humidity. The high humidity makes it difficult for them to pollinate well. You may need to hand pollinate. Tomatoes and tomatilloes are pollinated in the same way, so this article will help:
https://www.gardeningknowhow.com/edible/vegetables/tomato/pollinate-tomatoes.htm

Your tomatillos are ready to pick once the fruit gets firm and the husk gets dry, papery and straw colored.