My Honeydew melon vines seemed to be doing fine. But now, like overnight, the leaves are curling up to where they look like an old prize fighter's cauliflower ear. Why??
If it is Melon leaf curl virus, this is a relatively new disease and there is not much published on it as of yet. Because of this, I am unable to recommend what you can do for it. But, I do know that for most plant virus diseases, there is not much that can be done for the plant.
Leaf curl like that can be caused by aphids or Melon leaf curl virus.
This should help you if you believe it is aphids:
How do I remove whitefly honeydo from indoor carpet?
I would suggest consulting with a cleaning service for this matter.