Q.One Section Of Tree Sets Fruit Which Does Not Mature
I have an older peach tree that has 3 main branches. Two of them bear heavily each year, but one, apparently health looking branch, set lots of fruit but the fruit does not mature. I thin the fruit on the entire tree each year trying to use a minimum of 4″ spacing. At the start of the season the size of the fruit on the tree is uniform, but as the season progresses two-thirds of the tree has fruit mature at a normal rate while the one section is extremely slow and never develops mature fruit. It used to be fine, I don’t know what is different between the sections of the tree. this is the second or third year in a row for the one section to not mature. Any ideas why this would happen?

Certified GKH Gardening Expert
It is likely a branch that originates from the rootstock. This will be different than the grafted top. You will want to remove this branch at the base, and cut all new instances that arise from that spot, or below.
This article will help you to understand some of the factors that can lead to graft reversion:
This article will help you with peach tree care:
https://www.gardeningknowhow.com/edible/fruits/peach/peach-tree-care.htm